Objective: We evaluated the association between prescribed medications and mental status such as sleep, mood, and cognition in Korean elderly. Method: We investigated the number of medications of 604 individuals (281 men and 323 women) who taken prescription without major depressive disorder and dementia. They were enrolled in the Korean Longitudinal Study on Health and Aging (KLoSHA), a community-based cohort of aged ≥65 year. The daily total average number of medications used at least once a month including oral, injections, and external preparations except eye drops was calculated. The Pittsburgh Sleep Quality Index (PSQI), Korean version of the Geriatric Depression Scale (GDS-K), Subjective Memory Complain Questionnaire (SMCQ) were evaluated for subjective mental status. Results: The mean age of men and women was 76.10±8.33 and 75.20±7.86 years. The average number of medications used in men was 6.16±5.98 and in women was 5.53±5.77. The number of medications significantly correlated with PSQI score(r=0.14, 95% confidence interval (CI), 0.14 to 0.26) and GDS score (r=0.13, 95% CI, 0.02 to 0.25) in men but not in women. However it was not significant after adjusting for the illness burden of any comorbid illnesses. Conclusion: In elderly men, an increasing number of prescription medications have a relation to sleep quality and mood, unlike elderly women.