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Impacts of Comorbidities on the Association between Arterial Stiffness and Obstructive Sleep Apnea in the Elderly
Year of publication 2015
Title of paper Impacts of Comorbidities on the Association between Arterial Stiffness and Obstructive Sleep Apnea in the Elderly
Author Tae Kim, Chung Suk Lee, Sang Don Lee, Suk-Hoon Kang, Ji Won Han, Atul Malhotra, Ki Woong Kim, and In-Young Yoon
Publication in journal Respiration
Status of publication accepted
Vol 89(4)
Link https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846579/#!po=63.8889 231회 연결

Background

Although the impact of obstructive sleep apnea (OSA) on cardiovascular risk is reasonably well established in middle-aged patients, debate persists whether OSA also increases this risk in the elderly. Arterial stiffness has been used as an early independent predictor of cardiovascular risk.

Study Objectives

We sought to determine whether OSA had significant effects on the arterial stiffness in the elderly population and evaluate the impacts of comorbidities on the association between arterial stiffness and OSA.

Methods

We performed a cross-sectional study in a university hospital. Elderly participants (≥60 yr) were invited to participate in our study between November 2010 and January 2013. OSA was diagnosed using gold standard polysomnography and arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV) and cardio-ankle vascular index (CAVI) as well as by central systolic and diastolic blood pressure (cSBP and cDBP). High-sensitivity C-reactive protein (hs-CRP) level was also measured.

Results

We found no significant association between the severity of OSA and arterial stiffness-related parameters such as cSBP, cDBP, baPWV, CAVI, and hs-CRP. However, in patients without comorbid medical conditions or use of medications (n=101), we showed a modest association between OSA and arterial stiffness-related parameters and hs-CRP.

Conclusion

We conclude that OSA is associated with increased arterial stiffness in otherwise healthy elderly population, although the association was obviated by comorbidities and medications perhaps due to ceiling effects.