Background: Although the Mini-Mental Status Examination (MMSE) is the most widely used

screening instrument for dementia, it has several limitations. Methods: We developed and

validated a new scoring method of the MMSE, namely the short form of the MMSE (MMSE-S).

Results: The MMSE-S was more robust to demographic influences than the MMSE. The influence

of education, in particular, was smaller in the MMSE-S compared to the MMSE (p < 0.01).

The diagnostic accuracy of the MMSE-S for very mild to mild dementia was also better than

that of the original MMSE (p < 0.0001). Its specificity, in particular, was higher than that of the

original MMSE. In Korea, we could improve the post-test probability for dementia from 46.88

to 64.76% by employing the MMSE-S instead of the MMSE. We also provided optimal cut-off

scores for dementia stratified by age, education, and gender, which may further improve the

diagnostic accuracy of the MMSE-S for dementia. Conclusion: Due to its good accuracy and

brevity, the MMSE-S may contribute to enhancing the cost-effectiveness of and accessibility

to dementia screening as well as early diagnosis and treatment of dementia, particularly in

low- and middle-income countries.​