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The Effect of Choline Acetyltransferase Genotype on Donepezil Treatment Response in Patients with Alzheimer’s Disease
Year of publication 2015
Title of paper The Effect of Choline Acetyltransferase Genotype on Donepezil Treatment Response in Patients with Alzheimer’s Disease
Author Kang Uk Lee, Jung Hie Lee, Dong Young Lee, Jong Chul Youn, Jeong Lan Kim, Seok Woo Moon, Bong-Jo Kim, Seung-Ho Ryu, Moon Doo Kim, Chang-Uk Lee, Nam-Jin Lee, Sung Man Chang, Young Hoon Kim, Do Hoon Kim, Hae-Kook Lee, Jong Inn Woo, Ki Woong Kim, and Jin Hyeong Jhoo
Publication in journal Clinical Psychopharmacology and Neuroscience
Status of publication accepted
Vol 13(2)
Link https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540042/ 250회 연결

Objective

We examined the difference in responses to donepezil between carriers and non-carriers of the A allele at the +4 position of the choline acetyltransferase (ChAT) gene in Koreans.

Methods

Patients who met the criteria for probable Alzheimer’s disease (AD) (n=199) were recruited. Among these, 145 completed the 12-week follow-up evaluation and 135 completed the 26-week scheduled course. Differences and changes in the Korean version of the mini-mental state examination (MMSE-KC) score, Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Assessment Battery (CERAD-K[N]) wordlist subtest score (WSS), CERAD-K(N) total score (TS), and the Korean version of geriatric depression scale (GDS-K) score between baseline and 12 weeks or 26 weeks were assessed by the Student’s t-test.

Results

At 12 weeks, the changes in the MMSE-KC score, CERAD-K(N) WSS, and CERAD-K(N) TS from baseline were not significant between ChAT A allele carriers and non-carriers; however, at 26 weeks, these changes were significantly larger in ChAT A allele carriers than in non-carriers (p=0.02 for MMSE-KC and p=0.03 for CERAD-K(N) WSS respectively).

Conclusion

Our findings in this study suggested that presence of the A allele at the +4 position of ChAT might positively influence the treatment effect of donepezil in the early stages of AD in Koreans.