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A Systematic Review and Meta-Analysis of Nonpharmacological Interventions for Moderate to Severe Dementia | |
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Year of publication | 2019 |
Title of paper | A Systematic Review and Meta-Analysis of Nonpharmacological Interventions for Moderate to Severe Dementia |
Author | Riyoung Na, Ji-hye Yang, Yusung Yeom, You Joung Kim, Seonjeong Byun, Kiwon Kim, Ki Woong Kim |
Publication in journal | Psychiatry Investigation |
Status of publication | accepted |
Vol | 16(5) |
Link | https://www.psychiatryinvestigation.org/journal/view.php?doi=10.30773/… 184회 연결 |
ObjectiveDue to limited efficacy of medications, non-pharmacological interventions (NPI) are frequently co-administered to people with moderate to severe dementia (PWMSD). This systematic review and meta-analysis investigated the effects of NPI on activities of daily living (ADL), behavioral and psychological symptoms of dementia (BPSD), and cognition and quality of life (QoL) of PWMSD. MethodsA literature search was conducted in the following databases: Cochrane CENTRAL, EMBASE, Medline, CIHNAL, PsycINFO, KoreaMED, KMbase, and KISS. We conducted a meta-analysis on randomized controlled trials and used the generic inverse variance method with a fixed-effects model to calculate the standardized mean difference (SMD). The protocol had been registered (CRD42017058020). ResultsTen randomized controlled trials met the inclusion criteria of the current meta-analysis. NPI were effective in improving ADL [SMD=0.28, 95% confidence interval (CI)=0.11-0.45] and reducing depression (SMD=-0.44, 95% CI=-0.70- -0.19). However, NPI were not effective in reducing agitation, anxiety, or overall, or improving cognitive function. In a subgroup analysis, music therapy was effective in reducing overall BPSD (SMD=-0.52, 95% CI=-0.90- -0.13).
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