Drug addiction is a devastating brain disorder provoking severe social problems. Repeated drug exposure leads for a drug addict to recognize the drug as an increasingly salient stimulus. Thus, inhibition of early-phase drug sensitization is clinically important in that behavioral sensitization may play a role in subsequent drug dependence, such as reinstatement of drug seeking behaviors. In the present study, we investigated how an addicted brain is re-wired by repeated cocaine administration to be sensitized to cocaine. Our brain is equipped with a a signaling hub, the nucleus accumbens (NAc) that integrates glutamatergic inputs conveying information on context, motivation, and reward. NAc modulates behavioral outcomes by providing prioritizing signals to downstream basal ganglia. There are two types of projecting neurons (Go and No-go cells), which receive balanced innervation from prefrontal cortex (a decision center). We found that, in addicted state, however, prefrontal innervation is profoundly biased to Go cells of NAc. Moreover, such biased innervation was ameliorated by reducing cocaine-induced hyperactivation of prefrontal cortex using riluzole. Our study suggest that an early clinical intervention by reducing prefrontal activity using riluzole may reduce a drug-dependence of drug addicts.