Schizophrenia and related psychotic disorders are complex mental health conditions that show different brain disruptions depending on how patients respond to medication. For those who do respond to treatment, it's thought that there are issues in the prefrontal cortex that lead to problems with dopamine regulation in the brain. However, the link between changes in brain volume and dopamine function hasn't been thoroughly studied until now. This study explored the connection between dopamine activity and brain volume changes in both treatment-responsive and non-responsive patients. The findings revealed that treatment-responsive patients had a significant correlation between the grey matter volume in the prefrontal cortex and the capacity to produce dopamine in the striatum, a change not seen in non-responsive patients. These results are important because they not only confirm earlier findings about one hemisphere of the brain but also show similar results in both hemispheres. This supports the long-held belief that problems with dopamine regulation in the striatum are connected to abnormalities in the cortex in schizophrenia. Moreover, the findings suggest that different underlying mechanisms might explain why some patients respond to treatment while others do not, offering new insights into the treatment and understanding of psychotic disorders.