GLP-1 receptor agonists (GLP-1RAs) are effective in treating obesity, but how they work in the brain is not well understood. We gave GLP-1RAs to obese patients and noticed they felt full before eating. By studying brain samples from humans and mice, we identified certain neurons in the dorsomedial hypothalamus (DMH) that might be responsible for this feeling of fullness. When we used light to control these neurons, it also caused a feeling of fullness. Observing these neurons showed they are active in creating this feeling before eating. Giving GLP-1RAs increased the activity of these neurons specifically when eating. We also found that these DMH neurons interact with other neurons in the arcuate nucleus to control food intake. Our research highlights a specific brain mechanism through which GLP-1RAs help control hunger, suggesting new targets for treating obesity and related diseases.