2024 Selective reactivation of value- and place-dependent information during sharp-wave ripples in the intermediate and dorsal hippocampus
페이지 정보
작성자 최고관리자 작성일 24-07-03 16:17본문
- Journal
- Science Advances
- Journal Info
- 10(32)
- Year
- 2024
The hippocampus is crucial in episodic memory, which often consists of events associated with different values in a given space. In the hippocampus, highly synchronized activities of place cells encoding recent experiences are re-expressed during sharp-wave ripples (SWRs). Most prior studies focused on examining the sequential firing patterns of place cells during SWRs in the dorsal hippocampus (dHP), such as spatial replays reflecting recent navigational traces or paths toward goal locations. However, it is largely unknown that such reactivations are modulated by different values associated with places. In this study, we hypothesize that, in the intermediate hippocampus (iHP), the place cells representing higher-value locations are reactivated more than those representing lower-reward ones. To test it, we simultaneously recorded neural activities from single units in the dHP and iHP while rats performed a place-preference task on a T-maze. We found that high-value-coding place cells in the iHP were reactivated more frequently than low-value-coding place cells, but this finding was not observed in the dHP. Instead, precise spatial trajectories that sequentially lead to the goal locations were replayed in the dHP, whereas no sequential replay was observed in the iHP. Our findings suggest that value-based differential reactivation patterns along the dorsoventral axis of the hippocampus may play essential roles in optimizing goal-directed spatial learning for maximal reward.