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• Brain and Cognitive Sciences for the Future.pdf (1.6M) 1회 다운로드 | DATE : 2025-05-29 14:17:59
• Perminder Sachdev.pdf (2.5M) 1회 다운로드 | DATE : 2025-05-29 14:17:59

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뇌인지과학과에서는 이번 주 금요일에 세계적인 석학을 초빙하여 BCS 10-10 Focus Lecture Series 행사를 개최합니다.

Perminder Sachdev 교수님은 신경정신의학 분야의 세계적인 권위자로서 UNSW Center for Healthy Brain Aging (CHeBA) 센터의 공동 센터장을 맡고 계십니다. Sachdev 교수님은 노화에 따른 치매와 정신질환에 대한 연구로 잘 알려졌으며, 특히 치매의 예방과 조기 진단에 연구 활동의 많은 부분을 할애하여 왔습니다. 이번 강연을 통해 특히 "Maintain Your Brain (MYB) Trial" 이라는 CHeBA 센터 주도의 세계 최대 규모의 치매 예방 임상 시험에 대해 설명해 주시며 우리에게 치매에 대해 많은 것을 알려주실 것으로 기대됩니다.

관심있는 여러분의 많은 참여를 부탁드립니다.

ㅣ일시 : 5월 30일(금) 오후 4시

ㅣ장소 : 28동 301호 중형강의실

ㅣ연사 : Perminder Sachdev, MD, Ph.D (Scientia Professor of Neuropsychiatry, UNSW Sydney)

ㅣ주제 : "Preventing cognitive decline: the Maintain Your Brain Trial"

ㅣ초록 : Considering the contribution of modifiable risk factors to dementia burden worldwide, and the difficulties in developing effective drug treatments, there is a need for effective and scalable preventative interventions. A single-blind randomised controlled trial was conducted to assess an online multimodal lifestyle intervention for dementia prevention in the community over 3 years. Australian adults aged 55–77 years from Sax Institute’s 45 and Up Study with at least two modifiable dementia risk factors were eligible. Randomisation to intervention or control was automated at a 1:1 ratio with stratification by age, gender, total eligible risks, and dementia risk score. The intervention included a personalised schedule of online coaching in up to four risk areas (physical activity, nutrition, brain training, and depression and anxiety). Control participants received information only. The primary outcome was change in a global cognition composite (GCC) score comprised of complex attention, executive function, and learning and memory domains. Outcomes were measured every 12-months and analysis was intention-to-treat. This trial is registered at the Australian New Zealand Clinical Trials Registry (ACTRN 12618000851268). Between June 19, 2018, and October 15, 2018, 12,281 participants were screened with 6,104 randomised to MYB intervention (n = 3,051) or active control (n = 3,053) groups. At three years, the mean change in GCC z-score was 0.34 (SD) for intervention and 0.10 (SD) for control groups. The between-group difference in mean change was 0·181 (95% CI 0·134–0·228, p< 0·001). Trial-related adverse events occurred in 19 (0·6%) participants in the intervention group and one (0·03%) participant in the control group. Three year engagement with an online lifestyle intervention tailored to individual risk factor profiles significantly delayed cognitive decline in older adults. As the intervention is online and does not require in-person activities, the platform is scalable with potential for population-level roll-out that may help delay the onset of dementia in the general community.